Figure 8 | Scientific Reports

Figure 8

From: Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition

Figure 8

Model of Sap6 mediated cell-cell aggregation. C. albicans Sap6 contains amyloid regions (purple ovals) that function in autoaggregation by binding with hyphal surface Zap1 regulated proteins (blue ovals) and by binding with other amyloid regions mediated by zinc. Amyloid binding of zinc may also function to transfer zinc to fungal zinc transporters Zrt1/2 for uptake under zinc limiting environments. Sap6 RGD binding domains (red ovals) also binds cell surface RGD adhesins (gold circles) that contribute to autoaggregation.

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