Figure 3 | Scientific Reports

Figure 3

From: Maternal-placental-fetal biodistribution of multimodal polymeric nanoparticles in a pregnant rat model in mid and late gestation

Figure 3

Whole tissue fluorescence imaging of representative ED10 and ED20 tissues. Spectral unmixing was performed using a tube containing PGMA-PEI nanoparticles as reference. (a) Livers of ED10 dams. High levels of fluorescence were observed in livers from both PGMA and PGMA-PEI treated dams. (b) Other organs of ED10 dams. With the exception of the spleen of the PGMA-PEI treated dam, none of the organs showed a visible level of P10 fluorescence. (c) Uterine horns containing conceptuses of ED10 dams. In spite of spectral unmixing, low levels of autofluorescence was observed in controls and treated dams. (d) Uterine horns containing placentae and fetuses of ED20 dams. The placentae showed a visible level of autofluorescence in the P10 spectral region around the junctional zones in all dams. Images are representative of n = 4 per group.

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