Figure 2
From: Erythropoietin ameliorates diabetes-associated cognitive dysfunction in vitro and in vivo
The effects of EPO on HG-induced PC12 cell damage. (a) The effects of EPO on cell viability. PC12 cells were treated with 100 mM glucose and various doses of EPO for 48 h. The cell viability was measured by the MTT assay. (b) The effects of EPO on HG-induced LDH release. After the treatments mentioned above, the LDH assay was carried out using an LDH-cytotoxicity colorimetric assay kit. Data are expressed as the mean ± SEM, n = 5. *P < 0.05, **P < 0.01, versus control. # P < 0.05, ### P < 0.001, vs. the model. EPO (L), treatment with a low dose of EPO (8 U/mL); EPO (H), treatment with a high dose of EPO (16 U/mL); HG + EPO (L), treatment with 100 mM glucose and a low dose of EPO (8 U/mL); HG + EPO (L), treatment with 100 mM glucose and a high dose of EPO (16 U/mL).
