Figure 7
From: Erythropoietin ameliorates diabetes-associated cognitive dysfunction in vitro and in vivo
The involvement of EPOR/PI3K/GSK-3β in the protective effects of EPO in diabetic rats. (a) Hippocampal expression of EPOR mRNA. (b) Hippocampal expression of EPOR protein. (c) Hippocampal expression of PI3K mRNA. (d) Hippocampal expression of PI3K protein. (e) Hippocampal expression of GSK-3β mRNA. (f) Hippocampal expression of GSK-3β protein. (g) Hippocampal expression of p-Akt2 and the Akt2 protein. Gene expression was measured by real-time PCR. Relative mRNA abundance was measured in proportion to GAPDH. The results are shown as the mean ± SEM; n = 4. Protein expression levels in the lysates from freshly isolated hippocampus tissues were measured by Western blot analysis. The data are expressed as the mean ± SEM. *P < 0.05 and **P < 0.01 vs. the control group; # P < 0.05 and ## P < 0.01 vs. the model group.
