Figure 8
From: Erythropoietin ameliorates diabetes-associated cognitive dysfunction in vitro and in vivo
A diagram illustrating possible signaling pathways involved in EPO-mediated neuroprotection. EPO binds to EPOR and induces receptor dimerization, which leads to the activation of PI3K. Activated PI3K increases the phosphorylation of Akt2. p-Akt2 can inhibit the expression of GSK-3β, which is involved in the hyperphosphorylation of tau and the neurotoxicity of Aβ in AD. In addition, p-Akt2 is involved in the inhibition of cell apoptosis. Moreover, activated PI3K may play a vital role in ameliorating oxidative stress.
