Scientific Reports

Table 3 Urinary candidate biomarkers of tubular injury.

From: A comprehensive analysis and annotation of human normal urinary proteome

Protein Name	Uniprot ID	Protein Group	Nephron segment^{25, 40, 80}	Location	Molecular Function	Biomarker Application	Ref.
Beta-2-microglobulin	P61769	1D	Proximal tubule	Plasma Membrane	transmembrane receptor	Acute renal allograft rejection, acute kidney injury, diabetic nephropathy	81, 82
GST-alpha	P09210	1D	Proximal tubule	Cytoplasm	enzyme	Acute kidney injury	83
GSTP1	P09211	1D	Distal tubule	Cytoplasm	enzyme	Acute renal failure	81
Clusterin	P10909	1D	Proximal tubule & distal tubule	Cytoplasm	other	Renal-cell carcinoma, acute kidney injury	84
Cubilin	O60494	1D	Proximal tubule	Plasma Membrane	transmembrane receptor	Type 1 diabetes	85
Liver-type fatty acid-binding protein acid-binding protein	P07148	2D	Proximal tubule	Cytoplasm	transporter	Diabetic nephropathy, contrast nephropathy, IgA nephropathy	40
Heart-type fatty acid-binding protein	P05413	2D	Distal tubule	Cytoplasm	transporter	Acute kidney injury after cardiac surgery	86
Cystatin-C	P01034	1D	Glomerulus & proximal tubule	Extracellular Space	other	Acute kidney injury, acute renal dysfunction	87, 88
Calbindin	P05937	1D	Distal tubule & collecting duct	Cytoplasm	other	Distal nephron segment injuries	89
CYR61	O00622	2D	Proximal tubule	Extracellular Space	other	Glomerular disease	90
Alkaline phosphatase, tissue-nonspecific isozyme	P09923	2D	Proximal tubule	Plasma Membrane	phosphatase	Acute renal failure	91
Intestinal-type alkaline phosphatase	P05186	2D	Proximal tubule	Plasma Membrane	phosphatase	Diabetic nephropathy, acute renal failure	92
Alpha-N-acetylglucosaminidase	P54802	1D	Proximal tubule	Cytoplasm	enzyme	Acute kidney injury	93
Netrin-1	O95631	3D	Proximal tubule	Extracellular Space	growth factor	Acute kidney injury, diabetic nephropathy	94
Neutrophil gelatinase-associated lipocalin	P80188	1D	Proximal tubule & distal tubule	Extracellular Space	transporter	Acute kidney injury, chronic kidney disease	95
Osteopontin	P10451	1D	Proximal tubule & loop of henle & distal tubule	Extracellular Space	cytokine	Progressive renal injury	96
Interleukin-18	Q14116	2D	Proximal tubule	Extracellular Space	cytokine	Acute kidney injury	97
Retinol-binding protein	P02753, P82980, P50120, P09455	1D	Proximal tubule	Extracellular Space, Cytoplasm	transporter	Acute kidney injury, renal failure	98

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