Figure 5 | Scientific Reports

Figure 5

From: Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling

Figure 5

GTP cyclohydrolase 1 (GCH1) overexpression improves cardiac function 4 weeks after myocardial infarction (MI). (A) Left ventricular (LV) end-systolic pressure; (B) The rate of LV pressure rise (+dP/dt); (C) The LV end-diastolic pressure-volume relationship; (D) Heart weight normalized to body weight; (E) LV weight normalized to body weight: (F) Lung weight normalized to body weight. Figure legend: sham WT, wild-type mice receiving sham surgery; MI WT, wild-type mice undergoing myocardial infarction; sham Tg, transgenic GCH1 mice receiving sham surgery; MI Tg, transgenic GCH1 mice undergoing myocardial infarction. *P < 0.05 versus sham WT groups; †P < 0.05 versus MI WT groups (n = 8–10 mice/group).

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