Figure 8 | Scientific Reports

Figure 8

From: Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling

Figure 8

Effects of transgenic overexpression of human GTP cyclohydrolase 1 (GCH1) on GCH1 proteins and tetrahydrobiopterin in post-infarction remodeled myocardium. (A) Representative Western blot bands showing the expression of human and mouse GCH1 proteins and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as control in wild-type (WT) and transgenic (Tg) mice 4 weeks after myocardial infarction (MI) or sham surgery; (B) Total (human + mouse) GCH1 proteins normalized to GAPDH; C: cardiac tetrahydrobiopterin concentrations. *P < 0.05 versus sham WT groups; †P < 0.05 versus MI WT groups; #P < 0.05 versus sham Tg groups (n = 5–6 mice/group).

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