Table 2 Calculated pharmacokinetic parameters of patient 1 and 2.
From: Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
Patient 1 – Cefuroxime | Patient 2 – Cefazolin | |
|---|---|---|
Female, 60 kg | Male, 110 kg | |
Initial dose in g | 1.5 | 2.0 |
Estimated maximal concentration in µg ml −1 | 72.9 | 76.3 |
Half-life time in h | 1.3 | 1.3 |
Plasma protein binding in % | ||
Volume of distribution in L | 13.8 | 5.2 |
Clearance in L h −1 | 7.2 | 2.8 |
Time above 8 µg ml −1 in min | 60 | 111 |
