Table 2 The percentage of hypermethylated or hypomethylated differentially methylated cytosines (DMC) in each or the annotated region.
Hypermethylated (%) | Hypomethylated (%) | Total | OR (95% CI) | p-value | |
|---|---|---|---|---|---|
Total | 1,613 (33.2%) | 3,243 (66.8%) | 4,856 | ||
Gene Regions | |||||
TSS1500 | 237 (34.8%) | 445 (65.2%) | 682 | 1.083 (0.9133–1.284) | 0.3823 |
TSS200 | 86 (44.8%) | 106 (55.2%) | 192 | 16.78 (13.59–20.72) | <0.0001 |
5′UTR | 166 (34.0%) | 322 (66.0%) | 488 | 1.041 (0.8540–1.268) | 0.7302 |
1st Exon | 39 (33.3%) | 78 (66.7%) | 117 | 1.005 (0.6813–1.484) | 0.9424 |
Gene body | 705 (36.1%) | 1,249 (63.9%) | 1,954 | 0.7294 (0.6510–0.8173) | <0.0001 |
3′UTR | 77 (44.5%) | 96 (55.5%) | 173 | 1.643 (1.210–2.232) | 0.0018 |
Intragenic | 468 (27.6%) | 1,228 (72.4%) | 1,696 | 0.6707 (0.5896–0.7629) | <0.0001 |
CpG Island Regions | |||||
CGI | 270 (59.6%) | 183 (40.3%) | 453 | 1.954 (1.790–2.134) | <0.0001 |
Shores | 489 (40.5%) | 719 (59.5%) | 1,208 | 1.314 (1.208–1.429) | <0.0001 |
Shelves | 138 (28.3%) | 350 (71.7%) | 488 | 0.8374 (0.7227–0.9703) | <0.0001 |
Open sea | 716 (26.4%) | 1,991 (73.6%) | 2,707 | 0.6337 (0.5848–0.6866) | <0.0001 |
Enhancer Regions | |||||
Non-enhancer | 976 (37.4%) | 1,632 (62.6%) | 2,608 | ||
Enhancer | 637 (28.3%) | 1,611 (71.7%) | 2,248 | 0.6612 (0.5856–0.7464) | <0.0001 |
