Table 4 Distribution of IL-12A rs568408 allelic frequencies among asthmatic patients and comparison individuals after stratification by age and gender.

From: Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan

Allele

Cases (2 N = 396)

Controls (2 N = 906)

P-value

OR (95% CI)

aOR (95% CI)

n

%

n

%

Age (year)

 <37.7

 Allele G

149

76.0

393

86.9

 

1.00 (reference)

1.00 (reference)

 Allele A

47

24.0

59

13.1

0.0007*

2.10 (1.37–3.22)

2.05 (1.34–3.15)

≥37.7

 Allele G

168

84.0

393

86.6

 

1.00 (reference)

1.00 (reference)

 Allele A

32

16.0

61

13.4

0.3876

1.23 (0.77–1.95)

1.28 (0.80–2.04)

P for interaction = 0.09

Gender

Men

 Allele G

126

76.8

318

83.7

 

1.00 (reference)

1.00 (reference)

 Allele A

38

23.2

62

16.3

0.0593

1.55 (0.98–2.43)

1.47 (0.97–2.41)

Women

 Allele G

191

82.3

468

69.0

 

1.00 (reference)

1.00 (reference)

 Allele A

41

17.7

58

11.0

0.0131*

1.73 (1.12–2.67)

1.76 (1.14–2.72)

P for interaction = 0.72

  1. Abbreviations: OR, odds ratio; CI, confidence interval; aOR: adjusted OR; Model: explanatory variable = allele (treated as categorical variable), covariable = gender, dependent variable = asthma (upper panel); explanatory variable = allele (treated as categorical variable), covariable = age, dependent variable = asthma (lower panel); The significant P-value and odds ratio are bolded and marked with a star.
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