Table 3 Odds ratios (ORs) with 95% confidence intervals (CI) of having severe abnormality in items of CARS among genotypes of GABRB3 SNP rs2081648, GABRA5 SNP rs35586628, and GABRG3 SNP rs208129 in ASD patients.

From: GABAA receptor subunit gene polymorphisms predict symptom-based and developmental deficits in Chinese Han children and adolescents with autistic spectrum disorders

Gene

dbSNP ID

Items of CARS

Ref

Comparisons between genotypes

GABRB3

rs2081648

  

TT vs. TC

TT vs. CC

TC vs. CC

Visual response

4

3.54 (1.03–12.11)*

2.07 (0.97–4.41)

0.58 (0.32–1.06)

GABRA5

rs35586628

  

CC vs. CT

CC vs. TT

CT vs. TT

Verbal communication

4

3.80 (1.09–13.29)*

1.98 (0.92–4.24)

0.52 (0.28–0.96)*

GABRG3

rs208129

  

AA vs. TA

AA vs. TT

TA vs. TT

Imitative behavior

4

0.35 (0.12–0.99)*

0.49 (0.25–0.95)*

1.40 (0.79–2.48)

Activity level

4

0.14 (0.04–0.59)**

0.36 (0.14–0.90)*

2.49 (1.24–4.99)*

  1. Ratings in items of CARS with a four-point scale (1 = appropriate for age; 2 = mildly abnormal; 3 = moderately abnormal; 4 = severely abnormal). The reference (Ref) rating is 4 in an ordinal polytomous logistic regression analysis (while adjusting for sex, age, and IQ). ASD patients for GABRB3 rs2081648: n = 14 TT, n = 44 TC, and n = 41 CC. ASD patients for GABRA5 rs35586628: n = 18 CC, n = 42 CT, and n = 39 TT. ASD patients for GABRG3 rs208129: n = 26 TT, n = 43 TA, and n = 30 AA. *p < 0.05; **p < 0.01. ASD, autistic spectrum disorders; CARS, Childhood Autism Rating Scale; Ref, reference; vs., versus.
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