Table 4 Odds ratios (ORs) with 95% confidence intervals (CI) of existing relevant impairments in items of ABC among genotypes of GABRB3 SNP rs2081648, GABRA5 SNP rs35586628, and GABRG3 SNP rs208129 in ASD patients.

From: GABAA receptor subunit gene polymorphisms predict symptom-based and developmental deficits in Chinese Han children and adolescents with autistic spectrum disorders

Gene

dbSNP ID

Items of ABC

Ref

Comparisons between genotypes

GABRB3

rs2081648

  

TT vs. CC

TC vs. CC

TC vs. TT

(R) Has not developed any friendships

1

0.70 (0.16–3.12)

0.33 (0.12–0.93)*

0.48 (0.12–1.93)

GABRA5

rs35586628

  

CC vs. TT

CT vs. TT

CT vs. CC

(R) Does not reach out when reached for

1

0.48 (0.09–2.61)

3.29 (1.14–9.48)*

6.86 (1.33–35.40)*

(S) Sometimes shows no ‘startle response’ to loud noise

1

3.02 (0.86–10.63)

4.18 (1.53–11.41)**

1.39 (0.43–4.51)

(L) Cannot point to more than five named objects

1

2.64 (0.80–8.78)

0.61 (0.23–1.58)

0.23 (0.07–0.78)*

(L) Repeats sounds or words over and over

1

1.59 (0.48–5.29)

3.54 (1.38–9.04)**

2.23 (0.70–7.17)

GABRG3

rs208129

  

AA vs. TT

TA vs. TT

TA vs. AA

(s′) Strong reactions to changes in routine/environment

1

3.01 (0.79–11.54)

5.09 (1.46–17.77)*

1.69 (0.60–4.78)

(S) Sometimes painful stimuli such as bruises, cuts, and injections evoke no reaction

1

10.61 (1.21–92.92)*

14.42 (1.73–120.46)*

1.36 (0.49–3.76)

(L) Uses at least 15 but less than 30 spontaneous phrases daily to communicate

1

0.29 (0.09–0.94)*

0.98 (0.32–2.97)

3.34 (1.21–9.22)*

  1. Ratings in items of ABC with a two-point scale (0 = no; 1 = yes). The reference (Ref) rating is 1 in a binary logistic regression analysis (while adjusting for sex, age, and IQ). ASD patients for GABRB3 rs2081648: n = 14 TT, n = 44 TC, and n = 41 CC. ASD patients for GABRA5 rs35586628: n = 18 CC, n = 42 CT, and n = 39 TT. ASD patients for GABRG3 rs208129: n = 26 TT, n = 43 TA, and n = 30 AA. *p < 0.05; **p < 0.01. ABC, Autism Behavior Checklist; ASD, autistic spectrum disorders;  L, language; R, relating; S, sensory; s′, social and self-help; SNP, single-nucleotide polymorphism; Ref, reference; vs., versus.
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