Figure 4
From: Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg
PMX53 treatment attenuated the pathological damage of cGVHD mice. (A) Skin histologic examination by HE staining showed that the cGVHD mice subjected to PBS treatment presented with damaged skin, including thickening in the epithelial layer, a loss of hair follicles, a lack of subdermal fat and heavy collagen deposition. However, the PMX53 treatment group exhibited a relative well-organized structure of skin compared to control cGVHD mice, including a reduced thickness of epithelial layer, more hair follicles, increased thickness of subdermal fat layer and decreased collagen deposition. (B) Liver histologic examination revealed clear perivascular infiltration surrounding the bile duct (white arrows) in the cGVHD mice, whereas few infiltrated cells were observed in the PMX53 treatment group. At least five mice were used in each group (N = 5). Scale bar: 200 μm.
