Table 1 Clinical characteristics of the five FFI patients.
From: Clinical Features and Sleep Analysis of Chinese Patients with Fatal Familial Insomnia
| Â | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
|---|---|---|---|---|---|
Gender | M | F | F | F | M |
Age at onset (years) | 62 | 60 | 19 | 36 | 55 |
Onset to diagnosis duration (months) | 3 | 5 | 3 | 8 | 11 |
Onset to death duration (months) | 12 | 11 | 8 | 10 | 18 |
Cluster A—sleep-related symptoms | |||||
Insomnia | + | + | + | + | + |
Sleep-related involuntary movements | + | + | + | + | + |
Sleep-related dyspnea | + | + | + | + | + |
Laryngeal stridor | + | + | + | + | + |
Cluster B—neuropsychiatric symptoms | |||||
RPD | + | + | + | + | + |
Psychiatric symptoms | + | + | − | + | + |
Ataxia | − | + | + | + | + |
Pyramidal sign | − | − | + | + | − |
Parkinsonism | − | − | − | − | + |
Cluster C–progressive sympathetic symptoms | |||||
Autonomic symptoms | |||||
Hypertension | + | + | − | + | − |
Sweating | + | + | − | + | + |
Tachycardia | + | − | + | + | − |
Irregular breathing | − | − | + | − | − |
