Table 1 Severity of histological findings in EBOV-challenge animals treated with EBOTAb starting at days 1, 2 or 3 post-challenge.
Organ | Description | Treatment groups Animal ID’s (day post-challenge samples collected) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EBOTAb 1 day post-challenge | EBOTAb 2 days post-challenge | EBOTAb 3 days post-challenge | Untreated | |||||||||||
CCA087 (14) | CCB053 (14) | CCB077 (14) | CCB127 (14) | CCB037 (14) | CCB049 (14) | CCB081 (12) | CCB055 (12) | CCB079 (14) | CCB085 (9) | CCB130 (9) | CCB041 (9) | CCB080 (6) | ||
Spleen | Scattered, single cell destruction in red pulp | WNL | WNL | WNL | WNL | WNL | WNL | Mkd | WNL | WNL | Mod | Mkd | Mod | Mkd |
Scattered, single cell destruction in white pulp | WNL | WNL | WNL | WNL | WNL | WNL | Mkd | WNL | WNL | Mod | Mkd | Mild | Mkd | |
Lymphocyte loss in white pulp | WNL | WNL | WNL | WNL | WNL | WNL | Mkd | WNL | WNL | Mod | Mkd | Mild | Mod | |
Liver | Focal necrosis | Min | WNL | WNL | WNL | WNL | WNL | Mkd | WNL | WNL | Mod | Mkd | Mild | Mod |
Single cell, hepatocellular necrosis | WNL | WNL | WNL | WNL | WNL | WNL | Mod | WNL | WNL | Mod | Mod | Mod | Mod | |
Inguinal lymph nodes | Lymphocyte apoptosis | WNL | WNL | WNL | WNL | WNL | Min | Mkd | Mild | WNL | Mild | Mild | Mild | Mkd |
Lymphocyte paucity+/− macrophage prominence | WNL | WNL | WNL | WNL | WNL | WNL | Mkd | Mkd | WNL | Mod | Mild | Mild | Mod | |
Focal necrosis – medulla | WNL | WNL | WNL | WNL | WNL | Min | WNL | WNL | WNL | WNL | WNL | WNL | WNL | |
Lung | Infiltration by mixed inflammatory cells | WNL | WNL | WNL | WNL | Mild | WNL | WNL | WNL | WNL | Mild | WNL | WNL | WNL |
