Figure 2 | Scientific Reports

Figure 2

From: LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

Figure 2

Transplantation of LEA29Y-tg neonatal porcine islet-like clusters (NPICCs) into diabetic NSG mice carrying a human immune system (HU-SRC-SCID). (A) Development of normoglycemia (random blood glucose levels consistently <120 mg/dl), blood glucose (C) response and insulin secretion (D) during intraperitoneal glucose tolerance testing was comparable in humanized Tx-LEA-tg and immunodeficient NSG mice transplanted with equivalent numbers of NPICCs. The 125-day time course of mice with LEA-tg NPICCs shows normalization of blood glucose levels in n = 5 mice, near normal glucose levels in n = 2 animals, and persistent hyperglycemia in n = 1 mouse (B). In contrast, all Tx-wt remained hyperglycemic (Log-rank test p = 0.039) (A,B). N = number of animals examined per group.

Back to article page