Figure 4 | Scientific Reports

Figure 4

From: LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

Figure 4

Histological scoring of NPICC grafts and quantification of immune cell infiltration. (A) The beta cell insulin score was significantly higher in Tx-LEA-tg as compared to Tx-wt, whereas the insulitis score and the number of infiltrating hCD3+, hCD4+, and hCD8+ T cells was significantly lower in these animals (p < 0.05) (A). There was a non-significant trend towards a higher frequency of hCD68+ macrophages and a lower FoxP3+/CD4+ ratio in animals transplanted with wt NPICCs. N = number of animals examined per group. *p < 0.05 Tx-LEA-tg vs. Tx-wt.

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