Figure 1
From: Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6
Increased microtubule acetylation in CF/HDA mice. Nasal epithelium from wild-type (WT), F508del (CF), Hdac6−/− (HDA), and F508del/Hdac6 (CF/HDA) were excised, lysed, and analyzed via Western blot. Representative blots of 17 experiments are shown for acetylated-α-tubulin (ac-tub), α-tubulin, and actin (left). Gels are cropped for space. Full-length gels are provided in Supplemental Data. Quantification of ac-tub normalized to α-tubulin is shown (right). Significance between all groups was determined (*p < 0.05; n = 17; 1-way ANOVA with Newman-Keuls multiple comparison post hoc test). Data represent the means ± S.E.M.
