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Figure 3

From: A Nationwide Study of Severe and Protracted Diarrhoea in Patients with Primary Immunodeficiency Diseases

Figure 3

(A) Small intestine biopsy of patient 1 revealed marked villous atrophy and acute and chronic inflammation (hematoxylin-eosin [H&E] staining, magnification 100X) and (B) granulomatous inflammation (white arrows) composed of aggregates of epithelioid histiocytes in the lamina propria (H&E, 200X). (C,D) Colon biopsy of patient 1 showed ulceration and acute and chronic inflammation, with prominent epithelial apoptosis (white arrows) and intra-epithelial neutrophils (H&E, 400X).

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