Table 3 The relationship between mortality and the SD phenotype (severe and protracted diarrhoea) in each group of patients or whether directly related to SD or RD (refractory diarrhoea) phenotype.

Diseases	With SD phenotype		Without SD phenotype		Statistic test p value
	Alive	Death	Alive	Death	Kalpan-Meier survival*
	(patient number)		(patient number)		Kalpan-Meier survival*
XLA	6	0	4	2	0.0486
SCID	3	3	7	9	0.5122
WAS	1	2	15	4	0.066
CGD	3	1	15	2	0.5623
HIGM	2	1	10	0	0.3173
Total	15	7	51	17	0.9230
Mortality	SD phenotype		RD phenotype
	Non-related	Related	Non-related	Related
	7	0	0	2

*Kalpan-Meier survival analysis defined the diagnosis day as the first follow-up day to compare those PIDs patients with and without the SD phenotype. For those without SD, the starting time of K-M analysis was the diagnosis day by characteristic presentations or/and molecular and genetic confirmation. They had no the SD phenotype to date. For those with SD, the starting time of K-M analysis was the diagnosis day by characteristic presentations accompanying SD or/and molecular and genetic confirmation.

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