Figure 5
From: Revealing protein networks and gene-drug connectivity in cancer from direct information
Top 50 drug-mutated gene relationships inferred with direct couplings. Clusters are annotated with different colors based on the pathways to which the targets of drugs belong. Rectangles represent drugs and ellipses are the mutated genes. Red nodes indicate hubs connected to several drugs. Solid lines indicate that the gene product is known to relate with the target of the drug it connects, defined as known interactions, with thick solid edges indicating strong interactions between drug and mutated gene. The thin solid lines indicate a weaker relationship between drug and mutated gene. Dashed edges show predicted interactions between drug and mutated gene that have not been found in the literature. The edge coefficients represent the rank using direct information as a metric.
