Figure 2
From: Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex
Endogenous CS reduction prevents deprivation-induced amblyopia. (A–C) VEP amplitudes of the first negative peak (mean ± SEM) and averaged traces (inset, for low or middle spatial frequency) reveal typical acuity of the non-deprived eye regardless of genotype (A, black, WT; red, KO). The acuity reduction by monocular deprivation (MD) during the critical period (black, WT) failed in T1 KO mice (red) or in mice treated with ChABC (blue) (B). Scatter plots of visual acuity for each mouse (C) without MD (No-MD, WT, 0.53 ± 0.03; KO, 0.52 ± 0.03) or with MD at P24 (P24-MD WT, 0.31 ± 0.02; KO, 0.53 ± 0.01; ChABC, 0.54 ± 0.01; MD versus No-MD, p = 0.0001 for WT, p = 0.98 for KO, t-test).
