Figure 3
From: Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex
Endogenous CS reduction prevents ocular dominance plasticity. (A–C) Ocular dominance shift (toward group 4) is observed following MD in WT mice (A, No-MD, white bars; MD, gray bars; p < 0.0001, χ2-test), but is not induced in T1 KO mice (B, p > 0.05, χ2-test). High CBI values of each animal (C) typically shift following MD at P24 in WT mice (no-MD, 0.74 ± 0.02 versus P24-MD, 0.55 ± 0.02, p = 0.0003, t-test) but little shift is observed in T1 KO mice (no-MD, 0.72 ± 0.01 versus P24-MD, 0.69 ± 0.02, p = 0.14, t-test). Plasticity is not detected in adult WT (P60-MD, 0.70 ± 0.01) or T1 KO mice (P60-MD, 0.69 ± 0.02). contra, contralateral eye; ipsi, ipsilateral eye.
