Figure 9
From: Dysivillosins A–D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa
Comparison of the dysivillosin A (1) inhibited the activation of signaling molecules in antigen-stimulated RBL-2H3 cells. IgE-sensitized RBL-2H3 cells (2 × 106 cells/well) were stimulated with 1 μg/ml DNP-BSA for 15 min in the presence or absence of 1. The levels of p-Syk, Syk, p-PLCγ1 and PLCγ1 were measured by immunoblotting analysis. (a) The blots are representative of three independent experiments. (b) The data are presented as means ± SD. *P < 0.05, ***P < 0.001 versus DNP-BSA-treated group (n = 3). Data are analyzed by one-way ANOVA followed by Tukey’s Multiple Comparison Post-Test (GraphPad Prism 5.0).
