Figure 2
From: A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity
Binding of IMB-YH-8 to PknB as measured by surface plasmon resonance (a) and isothermal titration calorimetry (b). (a) Upper panel: Blank subtracted sensorgram for the binding of IMB-YH-8 (range from 12.5 to 200 μM). Lower panel: The affinity for IMB-YH-8 binding (K D = 25.3 μM) was calculated from the association equilibrium data. (b) Thermograms (upper panel) and binding isotherms with theoretical fits (lower panel) obtained for the binding of IMB-YH-8 to PknB.
