Table 1 Structure, LogP, enzyme inhibition activity against PknB, anti-tuberculosis activity, and selectivity of IMB-YH-8.

From: A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity

Compound

Structure

LogP a

PknB IC50 (μM)

H37Rv MIC (μg/ml)

THP-1 cell CC50 (μg/ml)

SIb

IMB-YH-8

2.022

20.2

0.25

7.61

30.4

  1. aLogP determined with Discovery Studio 2.5. bSI, selectivity index, calculated as the CC50/MIC.
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