Table 1 Univariate and multivariate analysis of DFS in HCC patients.

From: Hepatocyte nuclear factor-1beta enhances the stemness of hepatocellular carcinoma cells through activation of the Notch pathway

Variable

Number

Univariate analysis

Multivariate

P value

HR (95% CI)

P value

Tumour HNF-1B expression

 Low vs High

57 vs 33

0.001*

2.406 (1.415,4.092)

0.007*

Tumour size

 <5 cm vs ≥ 5 cm

38 vs 52

0.010*

 

NS

Tumour number

 Single vs Multiple

92 vs 8

0.339

 

NA

Cirrhosis

 No vs Yes

24 vs 66

0.001*

 

NS

TNM stage

 I/II vs III

82 vs 8

0.005*

3.596 (1.388,9.314)

0.008*

HbsAg

 Negative vs Positive

74 vs 16

0.794

 

NA

Serum AFP

 <400 vs ≥400

67 vs 23

0.499

 

NA

Edmondson grade

 I/II vs III

62 vs 28

0.021*

1.776 (1.086,2.907)

0.022*

Encapsulation

 No vs Yes

26 vs 64

0.142

 

NA

Portal vein thrombosis

    

 No vs Yes

65 vs 25

0.147

 

NA

Microvascular invasion

    

 No vs Yes

35 vs 55

0.451

 

NA

Macrovascular invasion

    

 No vs Yes

85 vs 5

0.005*

 

NS

  1. NA, not adopted; NS, not significant; HR, hazard ratio; Factors with p < 0.05 in univariate analysis were used for further multivariate analysis. *P < 0.05 was considered statistically significant.
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