Figure 1

Cumulative effect of the associated variants from gout associated loci and gout + SU associated loci on gout incidence. For the analysis using variants from the gout associated loci (GOUT, blue color), seven variants (rs1260326 (L446P)of GCKR, rs11722228 of SLC2A9, rs12505410 and rs2231142 (Q141K)of ABCG2, rs4073582 of CNIH2, rs671 (E504K) of ALDH2 (MYL2-CUX2) and rs9895661 of BCAS3) were included and eight bins (≤5, 6, 7, 8, 9, 10, 11, and ≥12) were generated. Using the ≤5 bin as the reference category, the OR and 95% CI for each of the other bins (6, 7, 8, 9, 10, 11, and ≥12) were assessed using logistic regression. For the combined analysis of variants from gout and SU associated loci (GOUT + SU, red color), we also used the ≤5 bin in the gout associated loci analysis as reference, and excluded the individuals with ≤8 risk alleles in the SU associated loci analysis from the test bins (Supplementary Methods).