Table 2 Association results for the selected important variants.

From: Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population

CHR

SNP

BP

A1

Freq.

OR

L95

U95

P

Reported gene (aa_change)

Gout or SU

2

rs1260326

27,730,940

C

0.378/0.456

0.698

0.576

0.845

2.23E-04

GCKR (L446P)

Gout, SU

2

rs2307394

148,716,428

T

0.443/0.457

0.918

0.762

1.104

0.3628

ORC4 (A78S)

SU

4

rs16890979

9,922,167

T

0.011/0.017

0.542

0.229

1.285

0.1644

SLC2A9 (V253I)

Gout, SU

4

rs3775948

9,995,182

G

0.322/0.402

0.738

0.604

0.903

3.09E-03

SLC2A9

Gout, SU

4

rs2231142

89,052,323

T

0.496/0.309

1.837

1.519

2.222

3.83E-10

ABCG2 (Q141K)

Gout, SU

4

rs72552713

89,052,957

A

0.009/0.005

1.404

0.5316

3.707

0.4936

ABCG2 (Q126X)

Gout, SU

6

rs11754288

25,776,949

A

0.155/0.184

0.582

0.443

0.764

9.58E-05

SLC17A4 (A318T)

SU

6

rs1165196

25,813,150

G

0.168/0.203

0.570

0.441

0.738

1.94E-05

SLC17A1 (I269T)

SU

11

rs4073582

66,050,712

A

0.013/0.020

0.431

0.198

0.938

0.0339

CNIH2

Gout

12

rs671

112,241,766

A

0.116/0.153

0.684

0.519

0.900

6.80E-03

ALDH2 (E504K)

Gout

  1. CHR, Chromosome; SNP, dbSNP rs number; BP, Position, based on hg19; A1, minor allele for the whole sample; Freq., frequency of A1 for cases/controls; OR, odds ratio, for A1; L95, the lower endpoint of the 95% confidence interval (CI); U95, the upper endpoint of the 95% confidence interval; P, p value. Reported gene(s), The reported gene(s) in the previous GWAS; aa_change, amino acid change; Gout or SU, indicating whether the locus found to be associated with gout or SU; The variants with p < 0.05 were indicated in bold. All the OR (95% CI) and p values reported in this study were based on the PCA adjustment analysis.
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