Figure 3
From: Pyroptosis, superinfection, and the maintenance of the latent reservoir in HIV-1 infection
Archiving of viral genomes in the agent-based model assuming a relatively weak immune response against the virus. Computer simulations with and without pyroptosis/superinfection of latently infected cells are compared. The simulation tracks the time when latent genomes are generated during the course of the in silico infection, and the graphs are frequency distributions of the creation times of all latent virus genomes that are present at 1000 days post infection (in the latent reservoir, i.e. in cells that do not contain productive virus). (A) It is assumed that the latent reservoir has a half-life of about 6 months2. Each time step of the simulation corresponds to 0.1 days, and the probabilities per time step are given as follows. A = 0.045, A0 = 0.0003, G = 0.0001, B = 0.36, H = 0.01. During infection, Q = 0.95 is the probability of productive infection. The probabilities of CTL proliferation and CTL-induced inhibition of virus replication are determined by parameters C = 0.5, and F = 0.1, respectively. (B) Same simulation, assuming that the latent reservoir has a half-life of about 31 months3. Parameters were the same, except A0 = 0.00006, G = 0.000015.
