Table 1 Parameters used in the HIV latency model.
From: Anti-proliferative therapy for HIV cure: a compound interest approach
Parameter | Value | Dimensions | Source | Meaning |
|---|---|---|---|---|
θ L | −5.2 × 10−4 | day−1 | net latent clearance rate on ART | |
δ L | 0.0155 | day−1 | calculated* | latent central memory cell death rate |
α L | 0.015 | day−1 | latent cell proliferation rate | |
α cm | 0.015 | day−1 | latent central memory cell Tcm proliferation rate | |
α em | 0.047 | day−1 | latent effector memory cell Tem proliferation rate | |
α n | 0.002 | day−1 | latent naïve cell Tn proliferation rate | |
ξ | 5.7 × 10−5 | day−1 | activation rate | |
α A | 0 | day−1 | active proliferation rate | |
δ A | 1.0 | day−1 | active death rate | |
τ | 10−4 | day−1 | probability of latency given infection | |
α S | 300 | cells/(μL-day) | susceptible growth rate | |
δ S | 0.2 | day−1 | susceptible death rate | |
β | 10−4 | μL/(virus-day) | HIV infectivity off ART | |
β ε | β(1 − ε) | μL/(virus-day) | HIV infectivity on ART (with efficacy \(\varepsilon \in [0,1]\)) | |
π | 103 | virus/(cell-day) | viral production rate | |
γ | 23 | day−1 | viral clearance rate |
