Figure 1
From: Down-regulation of KCa2.3 channels causes erectile dysfunction in mice
KCa channel expression in mouse corpus cavernosum. (A) Q-PCR showing the expression of KCa channel subtypes and in case of KCa1.1 subunit α and β1 in corpus cavernosum of wild type mice (WT). Q-PCR showing expression of (B) KCa2.3 (C) KCa1.1α and (D) KCa1.1β1 channels in corpus cavernosum from upregulated (KCa2.3T/T (−Dox)), WT, and down-regulated (KCa2.3T/T (+Dox)) mice. (E) Immunoblot bands for the KCa2.3 channels in corpus cavernosum from KCa2.3T/T (−Dox), WT, and KCa2.3T/T (+Dox) mice. (F) Immunoblot quantification for the KCa2.3 channels in corpus cavernosum from KCa2.3T/T (−Dox), WT, and KCa2.3T/T (+Dox) mice. Data are means ± SEM of 5–9 animals in each group. P ≤ 0.05 (*) versus KCa2.3T/T (+Dox) mice. Compared with one-way ANOVA followed by a Tukey multiple comparisons test or with a Student’s t-test. ≈Around.
