Figure 6
From: Down-regulation of KCa2.3 channels causes erectile dysfunction in mice
Concentration–response curves for different relaxant compounds (0.001–30 μM) dependent on nitric oxide and KCa2.3 opening in the corpus cavernosum from wild type (WT), KCa2.3T/T (−Dox) (overexpressed model) or KCa2.3T/T (+Dox) (down-regulated model) in the corpus cavernosum. (A) Concentration-response curves for acetylcholine within the KCa2.3 mouse model, (n = 6–9). (B) Concentration-response curves for NS309 within the KCa2.3 mouse model, (n = 6–9). (C) Concentration-response curves for acetylcholine with and without pre-stimulation with 0.5 μM NS309 in WT mice, (n = 6). (D) Concentration-response curves for sodium nitroprusside within the KCa2.3 mouse model. (E) Single concentration administration of 0.01 μM NS309 with and without apamin 0.5 μM in WT mice, (n = 6). Results are means ± S.E.M. P ≤ 0.05 (*), (n = 6–9), Student’s t-test or two-way ANOVA followed by Tukey post hoc test.
