Table 4 Operating characteristics of newer pleural fluid tests for identifying PPE from non-PPE.
From: Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions
Biomarker candidates | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | AUC (95% confidence interval) |
|---|---|---|---|---|---|---|
BPI | > 4.5 ng/ml | 86.8 | 90.7 | 85.5 | 91.6 | 0.946 (0.916–0.976) |
NGAL | > 169.9 ng/ml | 92.6 | 95.4 | 92.6 | 95.4 | 0.983 (0.969–0.997) |
AZU1 | > 18.8 ng/ml | 89.7 | 93.5 | 89.7 | 93.5 | 0.943 (0.903–0.982) |
Calprotectin | > 11.6 μg/ml | 73.5 | 99.1 | 98.0 | 85.6 | 0.931 (0.893–0.968) |
