Table 5 Diagnostic accuracy of individual pleural fluid tests for distinguishing CPPE as compared with UPPE.
From: Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions
Biomarker Candidates | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | OR (95% confidence interval) | AUC (95% confidence interval) |
|---|---|---|---|---|---|---|---|
BPI | > 10 ng/ml | 97.0 | 91.4 | 91.4 | 97.0 | 341.3 (33.7, 3458.1) | 0.966 (0.925–1.000) |
NGAL | > 600 ng/ml | 75.8 | 94.3 | 92.6 | 80.5 | 51.6 (10.1, 264.3) | 0.875 (0.788–0.963) |
AZU1 | > 175 ng/ml | 97.0 | 65.7 | 72.7 | 95.8 | 61.3 (7.4, 505.5) | 0.807 (0.700–0.914) |
Calprotectin | > 90 μg/ml | 81.8 | 94.3 | 93.1 | 84.6 | 74.3 (13.9, 398.1) | 0.937 (0.879–0.995) |
LDH | > 1000 U/l | 81.8 | 100 | 100 | 85.4 | 144 (48.0, 431.9) | 0.915 (0.836–0.994) |
Glucose | < 60 mg/dl | 75.8 | 100 | 100 | 81.4 | 104 (35.1, 307.8) | 0.907 (0.829–0.985) |
pH | < 7.2 | 75.8 | 100 | 100 | 81.4 | 104 (35.1, 307.8) | 0.947 (0.898–0.996) |
