Figure 9 | Scientific Reports

Figure 9

From: Microbial Antigens Stimulate Metalloprotease-7 Secretion in Human B-Lymphocytes Using mTOR-Dependent and Independent Pathways

Figure 9

Proposed mechanism of MMP-7-mediated shedding of Syndecan-4 in activated B-lymphocytes. Circulating B-lymphocytes release MMP-7 after CpG and β-glucan stimulation through activation of TLR9 and Dectin-1 receptors, respectively. While CpG-stimulation is Rapamycin sensitive (mTOR-mediated), β-glucan is not (mTOR-independent) indicating different activation pathways. MMP-7 release participates in the shedding of Syndecan-4.

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