Table 3 Predictive factors for TR-ROP in all infants.

From: Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis

Predictive factors

Crude

GA- and BW-adjusted*

Multivariable-adjusted

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

GA

0.40 (0.33–0.49)

<0.0001

0.50 (0.40–0.64)

<0.0001

0.47 (0.35–0.61)

<0.0001

BW

0.994 (0.992–0.995)

<0.0001

0.997 (0.995–0.999)

0.003

0.999 (0.997–1.001)

0.23

Male

1.20 (0.73–1.99)

0.47

1.41 (0.67–3.02)

0.37

  

LCC

12.69 (7.19–22.40)

<0.0001

3.12 (1.46–6.66)

0.003

2.76 (1.24–6.19)

0.01

Sepsis

7.28 (3.56–14.89)

<0.0001

1.89 (0.67–5.28)

0.23

  

PDA ligation

5.20 (2.66–10.14)

<0.0001

1.54 (0.63–3.79)

0.35

  

Transfusion

17.84 (9.43–33.77)

<0.0001

1.42 (0.57–3.56)

0.45

  

Use history of oxygen

34.62 (4.75–252.25)

0.0005

2.12 (0.25–18.18)

0.49

  

CPAP

8.88 (5.11–15.98)

<0.0001

3.94 (1.77–9.09)

0.007

3.78 (1.66–8.93)

0.002

BPD

17.63 (9.50–32.69)

<0.0001

1.35 (0.56–3.28)

0.50

  

IVH

4.04 (2.25–7.27)

<0.0001

1.01 (0.43–2.38)

0.97

  

PVL

2.57 (1.05–6.29)

0.04

3.91 (1.00–15.23)

0.05

2.96 (0.68–13.18)

0.15

Weight gain at 6 weeks after birth

0.995 (0.994–0.997)

<0.0001

0.999 (0.996–1.002)

0.56

  

Weight gain rate

0.919 (0.892–0.944)

<0.0001

0.981 (0.937–1.030)

0.43

  
  1. Abbreviations: TR-ROP, treatment-requiring retinopathy of prematurity; GA, gestational age; BW, birthweight; OR, odds ratio; CI, confidence interval; LCC, late-onset circulatory collapse; PDA, patent ductus arteriosus; CPAP, continuous positive airway pressure; PMA, postmenstrual age; BPD, bronchopulmonary dysplasia; CNS, central nervous systems; IVH, intraventricular hemorrhage; PVL, periventricular leukomalacia. *GA is BW-adjusted and BW is GA-adjusted.
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