Table 5 Predictive factors for TR-ROP in infants with any degree of ROP.

From: Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis

Predictive factors

Crude

GA- and BW-adjusted*

Multivariable-adjusted

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

GA

0.46 (0.37–0.58)

<0.0001

0.54 (0.42–0.69)

<0.0001

0.48 (0.36–0.64)

<0.0001

BW

0.995 (0.993–0.997)

<0.0001

0.998 (0.996–1.000)

0.03

1.000 (0.997–1.002)

0.81

Male

1.16 (0.62–2.07)

0.62

1.43 (0.67–3.08)

0.36

  

LCC

4.81 (2.59–8.93)

<0.0001

2.70 (1.26–5.79)

0.01

2.44 (1.08–5.56)

0.03

Sepsis

4.37 (1.87–10.21)

0.0007

2.15 (0.74–6.26)

0.16

  

PDA ligation

2.48 (1.18–5.21)

0.02

1.35 (0.55–3.32)

0.51

  

Transfusion

7.28 (3.66–14.49)

<0.0001

1.45 (0.58–3.65)

0.43

  

Use history of oxygen

7.64 (0.97–60.43)

0.05

1.57 (0.16–14.98)

0.70

  

CPAP

5.74 (3.08–11.07)

<0.0001

4.60 (2.01–11.01)

0.0003

4.50 (1.91–11.09)

0.0005

BPD

7.13 (3.66–13.92)

<0.0001

1.53 (0.64–3.67)

0.34

  

IVH

1.75 (0.92–3.35)

0.09

0.87 (0.37–2.02)

0.74

  

PVL

1.63 (0.59–4.55)

0.35

3.70 (0.90–15.19)

0.07

2.80 (0.62–13.80)

0.18

Weight gain at 6 weeks after birth

0.994 (0.992–0.997)

<0.0001

0.999 (0.996–1.002)

0.48

  

Weight gain rate

0.957 (0.922–0.990)

0.01

0.989 (0.944–1.039)

0.66

  
  1. Abbreviations: TR-ROP, treatment-requiring retinopathy of prematurity; GA, gestational age; BW, birthweight; OR, odds ratio; CI, confidence interval; LCC, late-onset circulatory collapse; PDA, patent ductus arteriosus; CPAP, continuous positive airway pressure; PMA, postmenstrual age; BPD, bronchopulmonary dysplasia; CNS, central nervous systems; IVH, intraventricular hemorrhage; PVL, periventricular leukomalacia. *GA is BW-adjusted and BW is GA-adjusted.
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