Figure 6
IC50 values for artemisinin and oxidants of Δpfaop knockout parasites. (a) Artemisinin dose-response curves (upper panel) and IC50 values (lower panel) of blood stage cultures of strains Δaop#1-3 from Fig. 4. (b,c) tBOOH and diamide (DIA) dose-response curves (upper panel) and IC50 values (lower panel). All data are the mean ± standard deviation of at least three independent triplicate measurements. Wild type strain 3D7 served as a control. None of the differences between the IC50 values was found to be significant (p > 0.05) based on statistical analyses in SigmaPlot 12.5 using the one way ANOVA method.
