Figure 1
From: Biomimetic Molecular Signaling using DNA Walkers on Microparticles
Demonstration of molecular walker release and capture. (a) A schematic shows the experimental steps for walker release and detection (b) A schematic shows how Cascade Blue dyed (blue) particles released the DNA walker in response to fuel; the DNA walker diffused to fluorescein-dyed (green) sensor particles and acted to de-quench Texas Red on their surfaces (arrows). (c) Fluorescence micrograph shows fluorescein dyed sensor particles and cascade blue release particles after incubation for 1 hour with fuel. (d) Fluorescence micrographs of the control system with blue particles bearing SB instead of the DNA walker after incubation for 1 hour with fuel. (e) Bar graph shows the average red fluorescence of the blue and green particles before and after addition of fuel from 8 or more images. Error bars represent the standard deviation of the particle intensities.
