Figure 5
From: The structure-function relationship of disulfide bonds in etanercept
Assessment of potency variability over time. Assessment of potency in reference product Enbrel® batches sourced from both the EU and US since 2008 reveals a broad distribution with a tightening of values toward the lower end over time, likely due to one or more process changes. Assessment of potency for GP2015 (Erelzi®) batches over time reveals low batch to batch variability well within the clinically verified range of the reference product. Manufacturing dates are given as month/year.
