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Figure 2

From: Predicting effects on oxaliplatin clearance: in vitro, kinetic and clinical studies of calcium- and magnesium-mediated oxaliplatin degradation

Figure 2

Time-course and mass balance analysis of oxaliplatin degradation in (A) water, (B) 150 mM NaCl, (C) 75 mM CaCl2, and (D) 75 mM MgCl2 solutions under physiological conditions (pH 7.3; 37 °C). Oxaliplatin was unstable in chloride containing solutions in contrast to its stability in water. Oxaliplatin degradation was accelerated in the presence of calcium and magnesium. Red: Intact oxaliplatin. Yellow: intermediate. Green: Pt(DACH)Cl2. Data points represent the mean of independent replicate measured values. The lines represent kinetic models shown in the text whose rate constants are shown in Table 1.

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