Figure 3 | Scientific Reports

Figure 3

From: Predicting effects on oxaliplatin clearance: in vitro, kinetic and clinical studies of calcium- and magnesium-mediated oxaliplatin degradation

Figure 3

Plasma calcium (A,B) and magnesium (C,D) concentrations in colorectal cancer patients measured before and after CaGluc/MgSO4 (red) or placebo (blue) infusions given with oxaliplatin chemotherapy. “Pre” and “post”refer to the timing of the plasma calcium and magnesium measurements before or after the CaGluc/MgSO4 infusions. The p values shown as p < 0.0001 are for a comparison of measurements determined with CaGluc/MgSO4 versus placebo infusions using repeated measures one way ANOVA, and those shown as *** (p < 0.001) or NS (not significant) are from Tukey’s multiple comparison test. Plasma calcium and magnesium concentrations were increased after CaGluc/MgSO4 infusions but not after placebo infusions. CaGluc/MgSO4: calcium gluconate/magnesium sulfate infusions.

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