Figure 4 | Scientific Reports

Figure 4

From: Predicting effects on oxaliplatin clearance: in vitro, kinetic and clinical studies of calcium- and magnesium-mediated oxaliplatin degradation

Figure 4

Correlation plots of oxaliplatin clearance versus plasma calcium (A) and magnesium (B) concentrations in colorectal cancer patients. Patients (n = 19) received CaGluc/MgSO4 and placebo infusions on alternate cycles of oxaliplatin treatment in random order, during which oxaliplatin clearance and plasma calcium and magnesium levels were measured. Data points represent oxaliplatin clearance values and the maximal plasma calcium and magnesium concentrations achieved during the placebo (blue) and CaGluc/MgSO4 infusion cycle (red) for each patient. Oxaliplatin clearance did not correlate with plasma calcium or magnesium concentrations (correlation coefficient = −0.38; r2 = 0.14; and p = 0.11). Vertical lines show Common Toxicity Criteria Adverse Event (CTCAE) severity gradings for hypercalcaemia and hypermagnesaemia. ULN: upper limit of normal.

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