Figure 2 | Scientific Reports

Figure 2

From: A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer’s Disease, Glioblastoma and Lung cancer

Figure 2

Overlaps between processes and pathways significantly enriched in Alzheimer’s disease (AD), lung cancer (LC) and glioblastoma (GBM). Grey circles represent each of the diseases studied, and their size is proportional to the total number of processes/pathways up- or down-regulated in each case. (a) Number of Biological Processes, and KEGG and Reactome pathways significantly up- and down-regulated (FDR ≤ 0.05) in at least two of the three diseases. Dark and light arrows represent pathways up- and down-regulated, respectively. The Processes/Pathways deregulated in two diseases are located in between their corresponding grey circles, and correspond to the 4 possible combinations: up or down in both diseases, up in one disease and down in the other, and vice versa. Green circles denote the number of pathways deregulated in the same direction in two diseases, while the orange circles denote numbers of pathways deregulated in opposite directions in two diseases. (b) The Pathways/Processes significantly enriched in all 3 diseases.

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