Figure 3
From: Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice
HFD increases TREM2 immunostaining in the brain. (A) Representative images of TREM2 staining in brains of mice fed ND or HFD. (B) Percentage of TREM2 stained area (N = 4 mice/gender/group). Analysis by two-way ANOVA; a significant interaction between diet and gender (F(1,12) = 5.82, p = 0.0328), and a significant main effects of diet (F(1,12) = 9.567, p = 0.0093) and gender (F(1,12) = 11.55, p = 0.0053). **p < 0.01 by Sidak’s multiple comparison test. (C) Significant positive correlation between Trem2 RNA expression and 6E10 staining (r = 0.78, p = 0.0006). (D) Significant positive correlation between TREM2 staining and 6E10 staining (r = 0.61, p = 0.015). Spearman’s correlation test. (N = 4/gender/group).
