Figure 5
From: Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice
HFD significantly affects the brain lipidomic profiles. MDMS-SL was performed using cortices of APP23 mice. N = 3 male and 3 female mice per diet. (A) List of quantified lipid classes, their abbreviations and color association for correlation matrices. (B) Principal component analysis showing significant differences in brain lipidomics profiles between mice fed HFD and ND, with each point representing a single animal. (C) Volcano plot showing molecular species within major lipid classes significantly impacted by HFD in APP23 mice. Significant species are colored red for higher in HFD and blue for lower in HFD.
