Figure 4

Functional clustering and physiological pathways associated with the differentially abundant proteins identified in vivax malaria. Pie charts showing the physiological pathways (A), biological process (B), molecular functions (C) and cellular components (D) related to the differentially abundant proteins identified in both LPVM and MPVM patients (combined list). Separate analyses of the two classes of vivax malaria patients (i.e. LPVM and MPVM) are provided in supplementary information (Fig. S3A and B). (E) Differential abundance of the serum proteins (light yellow) involved in lipid metabolism and molecular transport are depicted in a longitudinal cohort of vivax malaria patients (FEB, DEF and CON stages). The node color represents up (red) and down-regulated (green) proteins within the categories, and the color intensity demonstrates the magnitude of differential abundances. Light blue symbols represent the associated proteins identified in the functional analysis for which the differences in serum levels have not achieved statistical significance (p > 0.05) in our study.