Table 1 Differentially abundant serum proteins identified in the low and moderately-high parasitemic vivax malaria patients#.
Sl No. | Protein | Uniprot Accession ID | Unique Peptides (iTRAQ /DIGE) | Fold change HC vs. LPVM (iTRAQ/DIGE) | Fold change HC vs. MPVM (iTRAQ) | Fold change MPVM vs. LPVM (iTRAQ/DIGE) | Associated Pathways^ |
|---|---|---|---|---|---|---|---|
1 | Apolipoprotein E* | P02649 | 12/21 | 1.01/3.18 | 1.13 | 1.12 | Chylomicron-mediated lipid transport, HDL-mediated lipid transport, Scavenging by Class A Receptors, Retinoid metabolism and transport |
2 | Alpha-2-macroglobulin$ | P01023 | 63/39 | 0.79 | 0.78 | 0.98/0.38 | HDL-mediated lipid transport. Platelet degranulation. Intrinsic pathway of Fibrin Clot Formation. Degradation of the extracellular matrix. Rho GTPase cycle |
3 | Apolipoprotein A-II | P02652 | 7 | 0.72 | 0.48 | 0.66 | HDL-mediated lipid transport, Chylomicron-mediated lipid transport, Scavenging by Class A Receptors, Retinoid metabolism and transport |
4 | Apolipoprotein A1*$ | P02647 | 37/24 | 0.63 | 0.46 | 0.73/0.28–0.42 | ABC transporters in lipid homeostasis, Platelet degranulation, Chylomicron-mediated lipid transport, HDL-mediated lipid transport, PPARA activates gene expression, Scavenging of heme from plasma, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Retinoid metabolism and transport, Amyloids |
5 | Serum albumin†$ | P02768 | 26/30 | 0.47 | 0.35 | 0.73/0.33–0.40 | HDL-mediated lipid transport, Platelet degranulation, Recycling of bile acids and salts, Scavenging of heme from plasma and Transport of organic anions |
6 | Titin | Q8WZ42 | 2 | 1.69 | 3.77 | 2.23 | Striated muscle contraction, Platelet degranulation |
7 | Gelsolin | P06396 | 18 | 0.76 | 0.78 | 1.02 | Caspase-mediated cleavage of cytoskeletal proteins. Amyloid fiber formation |
8 | C-reactive protein | P02741 | 5 | 1.61 | 8.57 | 5.31 | Classical antibody-mediated complement activation |
9 | Complement component C9$ | P02748 | 5/11 | 1.11/3.5 | 1.43 | 1.29 | Terminal pathway of complement. Regulation of Complement cascade |
10 | Vitronectin | P04004 | 6 | 1.05 | 1.12 | 1.07 | Molecules associated with elastic fibres, Integrin cell surface interactions, Syndecan interactions, ECM proteoglycans, Regulation of Complement cascade |
11 | Hemoglobin subunit beta | P68871 | 10 | 1.17 | 1.76 | 1.5 | Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide, Scavenging of heme from plasma, Factors involved in megakaryocyte development and platelet production |
12 | Hemopexin* | P02790 | 18/17 | 1.05 | 1.14 | 1.09/1.56 | Scavenging of heme from plasma |
13 | Hemoglobin subunit alpha | P69905 | 7 | 1.05 | 1.52 | 1.45 | Erythrocytes take up carbon dioxide and release oxygen. Erythrocytes take up oxygen and release carbon dioxide. Scavenging of heme from plasma |
14 | Glutathione peroxidase 3 | P22352 | 2 | 1.03 | 0.69 | 0.67 | Detoxification of reactive oxygen species |
15 | Haptoglobin*$ | P00738 | 22/11 | 1.01/0.54 | 0.53 | 0.53/0.25–0.35 | Scavenging of heme from plasma |
16 | Alpha-1-antitrypsin$ | P01009 | 37/20 | 1.14/2.29 | 1.5 | 1.31 | Platelet degranulation |
17 | Clusterin$ | P10909 | 11/8 | 0.85 | 0.98 | 1.16/0.56–0.62 | Platelet degranulation |
18 | Serum amyloid A-1 protein* | P0DJI8 | 7 | 1.47 | 1.38 | 0.94 | RIP-mediated NFkB activation via ZBP1, Scavenging by Class B Receptors, DEx/H-box helicases activate type I IFN and inflammatory cytokines production, G alpha (q) signalling events, G alpha (i) signalling events, Formyl peptide receptors bind formyl peptides and many other ligands,TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation, Amyloids |
19 | Ig mu chain C region$ | P01871 | 15/8 | 1.33/2.48 | 1.34 | 1.01 | CD22 mediated BCR regulation. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
20 | Ceruloplasmin$ | P00450 | 28/18 | 1.17/2.33 | 1.37 | 1.17 | Metal ion SLC transporters, Iron uptake and transport |
21 | Leucine-rich alpha-2-glycoprotein | P02750 | 10 | 1.46 | 1.7 | 1.16 | — |
22 | Alpha-1-antichymotrypsin$ | P01011 | 24/18 | 1.39/3.48 | 1.79 | 1.29 | — |
23 | Inter-alpha-trypsin inhibitor heavy chain H4$ | Q14624 | 24/21 | 1.11/2.95 | 1.21 | 1.08 | — |
24 | Alpha-1B-glycoprotein$ | P04217 | 10/16 | 1.00/1.89–5.1 | 1.15 | 1.15 | — |
25 | Vacuolar protein sorting-associated protein 33B | Q9H267 | 2 | 0.92 | 1.93 | 2.11 | — |
26 | Myelin basic protein | P02686 | 2 | 0.8 | 2.06 | 2.58 | — |
